Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle

Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to suppress the immune response via T cell starvatio...

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Detalles Bibliográficos
Autores principales: Kaper, Thijs, Looger, Loren L, Takanaga, Hitomi, Platten, Michael, Steinman, Lawrence, Frommer, Wolf B
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988858/
https://www.ncbi.nlm.nih.gov/pubmed/17896864
http://dx.doi.org/10.1371/journal.pbio.0050257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988858/
https://www.ncbi.nlm.nih.gov/pubmed/17896864
http://dx.doi.org/10.1371/journal.pbio.0050257

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