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Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle
Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to suppress the immune response via T cell starvatio...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988858/ https://www.ncbi.nlm.nih.gov/pubmed/17896864 http://dx.doi.org/10.1371/journal.pbio.0050257 |