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GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells
Apoptosis may be regulated by oxidants such as peroxynitrite (ONOO(−)). The tumour suppressor, p53, has been reported to play a crucial role in apoptosis induced by oxidants, therefore we assessed the ability of a ONOO(−) donor, GEA 3162, to activate caspases and induce mitochondrial permeability in...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991334/ https://www.ncbi.nlm.nih.gov/pubmed/17681284 http://dx.doi.org/10.1016/j.bcp.2007.06.028 |