T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase Activity

The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell lines, A3G induces catastrophic hypermutation by deaminating the HIV-1 genome. Interestingly, studies suggest that endogenous A3G in T cells in...

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Detalles Bibliográficos
Autores principales: Thielen, Beth K, Klein, Kevin C, Walker, Lorne W, Rieck, Mary, Buckner, Jane H, Tomblingson, Garrett W, Lingappa, Jaisri R
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993843/
https://www.ncbi.nlm.nih.gov/pubmed/17892323
http://dx.doi.org/10.1371/journal.ppat.0030135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993843/
https://www.ncbi.nlm.nih.gov/pubmed/17892323
http://dx.doi.org/10.1371/journal.ppat.0030135

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