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T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase Activity
The deoxycytidine deaminase APOBEC3G (A3G) is expressed in human T cells and inhibits HIV-1 replication. When transfected into A3G-deficient epithelial cell lines, A3G induces catastrophic hypermutation by deaminating the HIV-1 genome. Interestingly, studies suggest that endogenous A3G in T cells in...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993843/ https://www.ncbi.nlm.nih.gov/pubmed/17892323 http://dx.doi.org/10.1371/journal.ppat.0030135 |