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Analysis of multiple single nucleotide polymorphisms closely positioned in the ovine PRNP gene using linear fluorescent probes and melting curve analysis

BACKGROUND: Resistance and susceptibility to scrapie has been associated with single nucleotide polymorphisms located within codons 136, 154 and 171 of the ovine prion protein gene (PRNP). Dual-labelled HyBeacon probes were developed to analyse single and clustered polymorphisms within these and nei...

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Detalles Bibliográficos
Autores principales: French, David J, Jones, Dominic, McDowell, David G, Thomson, Jim A, Debenham, Paul G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994165/
https://www.ncbi.nlm.nih.gov/pubmed/17683552
http://dx.doi.org/10.1186/1471-2334-7-90