Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone

Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin. However, low glucocorticoid levels caused by adrenal insufficiency mitigate against insulin resistance, hyperphagia and fat accretion in Pomc(−/−) mice. Upon exogenous glucocorticoid replacement,...

Descripción completa

Detalles Bibliográficos
Autores principales: Michailidou, Zoi, Coll, Anthony P, Kenyon, Christopher J, Morton, Nicholas M, O'Rahilly, Stephen, Seckl, Jonathan R, Chapman, Karen E
Formato: Texto
Lenguaje:English
Publicado: Society for Endocrinology 2007
Materias:
Regular Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994568/
https://www.ncbi.nlm.nih.gov/pubmed/17592030
http://dx.doi.org/10.1677/JOE-07-0090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994568/
https://www.ncbi.nlm.nih.gov/pubmed/17592030
http://dx.doi.org/10.1677/JOE-07-0090

Ejemplares similares