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CpG Island Methylation in a Mouse Model of Lymphoma Is Driven by the Genetic Configuration of Tumor Cells
Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer. Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological significance and the underlying mechanisms of tumor-specific aberrant promoter methylation remain unclear, but some evid...
Autores principales: | Opavsky, Rene, Wang, Shu-Huei, Trikha, Prashant, Raval, Aparna, Huang, Yuan, Wu, Yue-Zhong, Rodriguez, Benjamin, Keller, Benjamin, Liyanarachchi, Sandya, Wei, Guo, Davuluri, Ramana V, Weinstein, Michael, Felsher, Dean, Ostrowski, Michael, Leone, Gustavo, Plass, Christoph |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994712/ https://www.ncbi.nlm.nih.gov/pubmed/17907813 http://dx.doi.org/10.1371/journal.pgen.0030167 |
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