The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment

BACKGROUND: HIV-1 envelope glycoprotein (Env) induces membrane fusion as a result of sequential binding to CD4 and chemokine receptors (CCR5 or CXCR4). The critical determinants of CCR5 coreceptor function are the N-terminal domain (Nt) and the second extracellular loop. However, mutations in gp120...

Descripción completa

Detalles Bibliográficos
Autores principales: Melikyan, Gregory B, Platt, Emily J, Kabat, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995219/
https://www.ncbi.nlm.nih.gov/pubmed/17686153
http://dx.doi.org/10.1186/1742-4690-4-55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995219/
https://www.ncbi.nlm.nih.gov/pubmed/17686153
http://dx.doi.org/10.1186/1742-4690-4-55

Ejemplares similares