Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene

Mutations in PROP1 are a common genetic cause of multiple pituitary hormone deficiency (MPHD). We used a comparative genomics approach to predict the transcriptional regulatory domains of Prop1 and tested them in cell culture and mice. A BAC transgene containing Prop1 completely rescues the Prop1 mu...

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Detalles Bibliográficos
Autores principales: Ward, Robert D., Davis, Shannon W., Cho, MinChul, Esposito, Constance, Lyons, Robert H., Cheng, Jan-Fang, Rubin, Edward M., Rhodes, Simon J., Raetzman, Lori T., Smith, Timothy P. L., Camper, Sally A.
Formato: Texto
Lenguaje:English
Publicado: Springer New York 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1998882/
https://www.ncbi.nlm.nih.gov/pubmed/17557180
http://dx.doi.org/10.1007/s00335-007-9008-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1998882/
https://www.ncbi.nlm.nih.gov/pubmed/17557180
http://dx.doi.org/10.1007/s00335-007-9008-6

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