Universally Sloppy Parameter Sensitivities in Systems Biology Models

Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring in vivo biochemical parameters is difficult, and collective...

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Detalles Bibliográficos
Autores principales: Gutenkunst, Ryan N, Waterfall, Joshua J, Casey, Fergal P, Brown, Kevin S, Myers, Christopher R, Sethna, James P
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000971/
https://www.ncbi.nlm.nih.gov/pubmed/17922568
http://dx.doi.org/10.1371/journal.pcbi.0030189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000971/
https://www.ncbi.nlm.nih.gov/pubmed/17922568
http://dx.doi.org/10.1371/journal.pcbi.0030189

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