Cargando…

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.

During recent years N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been developed as targetable drug carriers. These soluble synthetic polymers are internalized by cells by pinocytosis and they can be tailor-made to include peptidyl side-chains degradable intracellularly by specific lysoso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duncan, R., Kopecková-Rejmanová, P., Strohalm, J., Hume, I., Cable, H. C., Pohl, J., Lloyd, J. B., Kopecek, J.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1987
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002078/ https://www.ncbi.nlm.nih.gov/pubmed/3468994

Ejemplares similares

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.
por: Duncan, R., et al.
Publicado: (1988)

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat.
por: Wedge, S. R., et al.
Publicado: (1991)

N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.
por: Seymour, L. W., et al.
Publicado: (1991)

N-(2-hydroxypropyl)methacrylamide–amphotericin B (HPMA–AmB) copolymer conjugates as antileishmanial agents
por: Nicoletti, Salvatore, et al.
Publicado: (2009)

Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates
por: Rani, Sarita, et al.
Publicado: (2021)

Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins
por: Janisova, Larisa, et al.
Publicado: (2020)

Combination Chemotherapy and Photodynamic Therapy with Fab′ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells
por: Hongrapipat, Jarunee, et al.
Publicado: (2008)

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe(2)O(3) nanoparticles towards human tumor cells
por: Plichta, Zdeněk, et al.
Publicado: (2018)

Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate
por: Visone, Valeria, et al.
Publicado: (2020)

Influence of the Drug Position on Bioactivity in Angiopep-2—Daunomycin Conjugates
por: Pethő, Lilla, et al.
Publicado: (2023)

The Anticancer Drug Daunomycin Directly Affects Gene Expression and DNA Structure
por: Nishio, Takashi, et al.
Publicado: (2023)

In vitro activity of daunomycin-anti-alphafoetoprotein conjugate on mouse hepatoma cells.
por: Belles-Isles, M., et al.
Publicado: (1980)

Reproductive toxicology. Methacrylamide.
Publicado: (1997)

Development of novel cyclic NGR peptide–daunomycin conjugates with dual targeting property
por: Tripodi, Andrea Angelo Pierluigi, et al.
Publicado: (2018)

Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques
por: Borbély, Adina, et al.
Publicado: (2021)

Reduction of daunomycin toxicity by razoxane.
por: Wang, G., et al.
Publicado: (1981)

Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
por: García-Peñas, Alberto, et al.
Publicado: (2019)

HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells
por: Peng, Zheng-Hong, et al.
Publicado: (2014)

The use of poly(N-[2-hydroxypropyl]-methacrylamide) hydrogel to repair a T10 spinal cord hemisection in rat: a behavioural, electrophysiological and anatomical examination
por: Pertici, Vincent, et al.
Publicado: (2013)

Phage Display-Based Homing Peptide-Daunomycin Conjugates for Selective Drug Targeting to PANC-1 Pancreatic Cancer
por: Dókus, Levente E., et al.
Publicado: (2020)

Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry
por: Reddi, Rambabu N., et al.
Publicado: (2021)

Synthesis, characterization and osteogenesis of phosphorylated methacrylamide chitosan hydrogels
por: Yang, Huishang, et al.
Publicado: (2018)

Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[N-(2-hydroxypropyl)methacrylamide]-Block-Poly[N-(2,2-difluoroethyl)acrylamide], Prominent (19)F MRI Tracer
por: Babuka, David, et al.
Publicado: (2020)

Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cells
por: Napoli, Sara, et al.
Publicado: (2006)

THE EFFECT OF PUROMYCIN ON INTRANUCLEAR STEPS IN RIBOSOME BIOSYNTHESIS
por: Soeiro, R., et al.
Publicado: (1968)

Heparin does not modify plasma daunomycin disappearance in acute leukaemia patients.
por: Piazza, E., et al.
Publicado: (1980)

Overcharging Effect in Electrospray Ionization Mass Spectra of Daunomycin-Tuftsin Bioconjugates
por: Pethő, Lilla, et al.
Publicado: (2019)

Growth conditions, physiological properties, and selection of optimal parameters of biodegradation of anticancer drug daunomycin in industrial effluents by Bjerkandera adusta CCBAS930
por: Korniłłowicz-Kowalska, Teresa, et al.
Publicado: (2019)

Renal and haemopoietic proliferative defects as a delayed consequence of cis-platin, adriamycin and daunomycin treatments.
por: Braunschweiger, P. G., et al.
Publicado: (1982)

EFFECTS OF PUROMYCIN ON THE NUCLEOPROTEINS OF THE HELA CELL
por: Studzinski, G. P., et al.
Publicado: (1964)

Inadvertent intrathecal administration of daunomycin resulting in fatality: Case report and therapeutic considerations
por: Soldozy, Sauson, et al.
Publicado: (2020)

Conjugation of Cetuximab – Puromycin and Its Target-Specific Effect on Triple Negative Breast Cancer Cell Lines
por: Puspitasari, Diah, et al.
Publicado: (2022)

Further observations on restoration of memory lost after treatment with puromycin.
por: Flexner, J. B., et al.
Publicado: (1969)

2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent
por: Yokoo, Masako, et al.
Publicado: (2015)

Structure of puromycin-sensitive aminopeptidase and polyglutamine binding
por: Madabushi, Sowmya, et al.
Publicado: (2023)

Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model
por: Novy, Zbynek, et al.
Publicado: (2020)

Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model
por: Patil, Pritam S., et al.
Publicado: (2018)

L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia.
por: Warrington, R. C., et al.
Publicado: (1989)

INHIBITING EFFECT OF THE NEW CYTOTOXIC ANTIBIOTIC DAUNOMYCIN ON NUCLEIC ACIDS AND MITOTIC ACTIVITY OF HELA CELLS
por: Di Marco, A., et al.
Publicado: (1965)

Molecular Recognition of Parallel G-quadruplex [d-(TTGGGGT)](4) Containing Tetrahymena Telomeric DNA Sequence by Anticancer Drug Daunomycin: NMR-Based Structure and Thermal Stability
por: Barthwal, Ritu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_01crtj18qpedfc97ok9vmdrc6k