Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride

Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after...

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Detalles Bibliográficos
Autores principales: Pound, A. W., Lawson, T. A., Horn, Lorraine
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008820/
https://www.ncbi.nlm.nih.gov/pubmed/4352790
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author Pound, A. W.
Lawson, T. A.
Horn, Lorraine
author_facet Pound, A. W.
Lawson, T. A.
Horn, Lorraine
author_sort Pound, A. W.
collection PubMed
description Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours formed in the kidneys and the number in the liver was increased. When given after 60 hours, the incidence of kidney tumours was less but that of liver tumours was further increased. A larger dose of DMN (40 mg/kg) was tolerated 42 hours after CC1(4) and enhanced the number of kidney and liver tumours, the latter apparently due to an increased proportion of cholangiomata. Numerous small focal proliferations of atypical liver cells and of bile duct epithelium were observed after treatment with DMN. The incidence of these lesions in the different experimental treatments varied in a similar manner to the liver tumours. IMAGES:
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spelling pubmed-20088202009-09-10 Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride Pound, A. W. Lawson, T. A. Horn, Lorraine Br J Cancer Articles Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours formed in the kidneys and the number in the liver was increased. When given after 60 hours, the incidence of kidney tumours was less but that of liver tumours was further increased. A larger dose of DMN (40 mg/kg) was tolerated 42 hours after CC1(4) and enhanced the number of kidney and liver tumours, the latter apparently due to an increased proportion of cholangiomata. Numerous small focal proliferations of atypical liver cells and of bile duct epithelium were observed after treatment with DMN. The incidence of these lesions in the different experimental treatments varied in a similar manner to the liver tumours. IMAGES: Nature Publishing Group 1973-06 /pmc/articles/PMC2008820/ /pubmed/4352790 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Pound, A. W.
Lawson, T. A.
Horn, Lorraine
Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride
title Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride
title_full Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride
title_fullStr Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride
title_full_unstemmed Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride
title_short Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administaion of Carbon Tetrachloride
title_sort increased carcinogenic action of dimethylnitrosamine after prior administaion of carbon tetrachloride
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008820/
https://www.ncbi.nlm.nih.gov/pubmed/4352790
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