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Effect of Interaction Between Methotrexate and Dihydrofolate Reductase on DNA Synthesis in L1210 Cells In Vitro
L1210 leukaemia cells were preloaded with [(3)H methotrexate] (MTX) to saturate high-affinity intracellular sites, and were then incubated with [(3)H]MTX to determine the steady-state intracellular MTX concentrations at extracellular concentrations ranging from 10 μM to zero. In addition, incubation...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1978
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009514/ https://www.ncbi.nlm.nih.gov/pubmed/638018 |