Split dose cytotoxic experiments with misonidazole.

The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal...

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Detalles Bibliográficos
Autor principal: Stratford, I. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009678/
https://www.ncbi.nlm.nih.gov/pubmed/687510
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author Stratford, I. J.
author_facet Stratford, I. J.
author_sort Stratford, I. J.
collection PubMed
description The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repaired" by O2, the magnitude of this repair being time dependent and a function of O2 concentration, with maximum repair in air seen after 2 h at 37 degree C. Unlike radiation damage this repair is not inhibited by modest hyperthermia (41 degrees C) during the split-dose interval. The implication of these results as regards the mechanism of misonidazole toxicity under anaerobic conditions is discussed.
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spelling pubmed-20096782009-09-10 Split dose cytotoxic experiments with misonidazole. Stratford, I. J. Br J Cancer Research Article The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repaired" by O2, the magnitude of this repair being time dependent and a function of O2 concentration, with maximum repair in air seen after 2 h at 37 degree C. Unlike radiation damage this repair is not inhibited by modest hyperthermia (41 degrees C) during the split-dose interval. The implication of these results as regards the mechanism of misonidazole toxicity under anaerobic conditions is discussed. Nature Publishing Group 1978-07 /pmc/articles/PMC2009678/ /pubmed/687510 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Stratford, I. J.
Split dose cytotoxic experiments with misonidazole.
title Split dose cytotoxic experiments with misonidazole.
title_full Split dose cytotoxic experiments with misonidazole.
title_fullStr Split dose cytotoxic experiments with misonidazole.
title_full_unstemmed Split dose cytotoxic experiments with misonidazole.
title_short Split dose cytotoxic experiments with misonidazole.
title_sort split dose cytotoxic experiments with misonidazole.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009678/
https://www.ncbi.nlm.nih.gov/pubmed/687510
work_keys_str_mv AT stratfordij splitdosecytotoxicexperimentswithmisonidazole

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