Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.

Bilateral kidney ligation of mice immediately before injection of misonidazole (MIS) prolongs the plasma half-life of this radiosensitizer from about 2 h (in normal mice) to 10-11 h, similar to that in man. Kidney ligation does not, however, change the relative proportions of MIS and its O-demethyla...

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Detalles Bibliográficos
Autores principales: Brown, J. M., Yu, N. Y., Workman, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009863/
https://www.ncbi.nlm.nih.gov/pubmed/465300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009863/
https://www.ncbi.nlm.nih.gov/pubmed/465300

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