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Inhibition of DNA synthesis by nitroheterocycles. II. Mechanisms of cytotoxicity.

Nitroheterocycles have been shown to inhibit the incorporation of 3H-TdR by cultured L-929 cells, and the degree of inhibition is related to their electron-affinity. On the basis of their chemical reactivity and potential clinical utility, nitrofurazone, misonidazole and metronidazole were selected...

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Detalles Bibliográficos
Autor principal: Olive, P. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009955/
https://www.ncbi.nlm.nih.gov/pubmed/475964