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Inhibition of DNA synthesis by nitroheterocycles. II. Mechanisms of cytotoxicity.
Nitroheterocycles have been shown to inhibit the incorporation of 3H-TdR by cultured L-929 cells, and the degree of inhibition is related to their electron-affinity. On the basis of their chemical reactivity and potential clinical utility, nitrofurazone, misonidazole and metronidazole were selected...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
1979
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009955/ https://www.ncbi.nlm.nih.gov/pubmed/475964 |