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Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats.

Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely; 4 weeks we...

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Detalles Bibliográficos
Autores principales: Barbason, H., Smoliar, V., Fridman-Manduzio, A., Betz, E. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010017/
https://www.ncbi.nlm.nih.gov/pubmed/475971