Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.

An electrolytic reduction system has been developed to model the cytotoxic action of a range of nitroimidazole drugs against DNA hypoxic cells or anaerobic microorganisms. THe degree of damage induced by these drugs (measured as the release of [14C]-dT from DNA) and their relative rates of reduction...

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Detalles Bibliográficos
Autores principales: Knox, R. J., Knight, R. C., Edwards, D. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010832/
https://www.ncbi.nlm.nih.gov/pubmed/7032569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010832/
https://www.ncbi.nlm.nih.gov/pubmed/7032569

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