Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.

An electrolytic reduction system has been developed to model the cytotoxic action of a range of nitroimidazole drugs against DNA hypoxic cells or anaerobic microorganisms. THe degree of damage induced by these drugs (measured as the release of [14C]-dT from DNA) and their relative rates of reduction...

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Autores principales: Knox, R. J., Knight, R. C., Edwards, D. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1981
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010832/
https://www.ncbi.nlm.nih.gov/pubmed/7032569
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author Knox, R. J.
Knight, R. C.
Edwards, D. I.
author_facet Knox, R. J.
Knight, R. C.
Edwards, D. I.
author_sort Knox, R. J.
collection PubMed
description An electrolytic reduction system has been developed to model the cytotoxic action of a range of nitroimidazole drugs against DNA hypoxic cells or anaerobic microorganisms. THe degree of damage induced by these drugs (measured as the release of [14C]-dT from DNA) and their relative rates of reduction have been correlated with their redox potentials. The results show that the correlation of drug-induced damage and electron affinity is related to the amount of drug reduced, and supports the hypothesis that at the molecular level the cytotoxic mechanism of reduced nitroimidazoles is identical in hypoxic mammalian cells, bacteria and protozoa.
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spelling pubmed-20108322009-09-10 Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships. Knox, R. J. Knight, R. C. Edwards, D. I. Br J Cancer Research Article An electrolytic reduction system has been developed to model the cytotoxic action of a range of nitroimidazole drugs against DNA hypoxic cells or anaerobic microorganisms. THe degree of damage induced by these drugs (measured as the release of [14C]-dT from DNA) and their relative rates of reduction have been correlated with their redox potentials. The results show that the correlation of drug-induced damage and electron affinity is related to the amount of drug reduced, and supports the hypothesis that at the molecular level the cytotoxic mechanism of reduced nitroimidazoles is identical in hypoxic mammalian cells, bacteria and protozoa. Nature Publishing Group 1981-11 /pmc/articles/PMC2010832/ /pubmed/7032569 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Knox, R. J.
Knight, R. C.
Edwards, D. I.
Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
title Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
title_full Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
title_fullStr Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
title_full_unstemmed Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
title_short Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
title_sort interaction of nitroimidazole drugs with dna in vitro: structure-activity relationships.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010832/
https://www.ncbi.nlm.nih.gov/pubmed/7032569
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AT knightrc interactionofnitroimidazoledrugswithdnainvitrostructureactivityrelationships
AT edwardsdi interactionofnitroimidazoledrugswithdnainvitrostructureactivityrelationships

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