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Response of a high-glucuronidase human tumour xenograft to aniline mustard.

The HT29R colonic adenocarcinoma xenograft has been shown to be rich in the enzyme beta-glucuronidase. Experiments in rodent systems have demonstrated a marked anti-tumour effect of the drug aniline mustard (AM) on tumours with high levels of this enzyme (e.g. the plasmacytomas PC5 and PC6). We have...

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Detalles Bibliográficos
Autores principales: Warenius, H. M., Workman, P., Bleehen, N. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1982
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010942/
https://www.ncbi.nlm.nih.gov/pubmed/7059462