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DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase
DNA polymerases achieve high-fidelity DNA replication in part by checking the accuracy of each nucleotide that is incorporated and, if a mistake is made, the incorrect nucleotide is removed before further primer extension takes place. In order to proofread, the primer-end must be separated from the...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018640/ https://www.ncbi.nlm.nih.gov/pubmed/17702757 http://dx.doi.org/10.1093/nar/gkm591 |