A persistent RNA·DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro

Expansion of an unstable GAA·TTC repeat in the first intron of the FXN gene causes Friedreich ataxia by reducing frataxin expression. Deficiency of frataxin, an essential mitochondrial protein, leads to progressive neurodegeneration and cardiomyopathy. The degree of frataxin reduction correlates wit...

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Detalles Bibliográficos
Autores principales: Grabczyk, Ed, Mancuso, Miriam, Sammarco, Mimi C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018641/
https://www.ncbi.nlm.nih.gov/pubmed/17693431
http://dx.doi.org/10.1093/nar/gkm589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018641/
https://www.ncbi.nlm.nih.gov/pubmed/17693431
http://dx.doi.org/10.1093/nar/gkm589

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