Metabolic conversion of methoxymorpholinyl doxorubicin: from a DNA strand breaker to a DNA cross-linker.

Methoxymorpholinyl doxorubicin (MMDX) is a novel anti-cancer anthracycline that differs from doxorubicin in its mechanisms of action, pattern of resistance and metabolism. Whereas doxorubicin is primarily an inhibitor of topoisomerase II, MMDX inhibits both topoisomerases I and II, resulting in pred...

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Detalles Bibliográficos
Autores principales: Lau, D. H., Duran, G. E., Lewis, A. D., Sikic, B. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033319/
https://www.ncbi.nlm.nih.gov/pubmed/8018545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033319/
https://www.ncbi.nlm.nih.gov/pubmed/8018545

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