Deletion analysis of chromosome 8p in sporadic colorectal adenomas.

In order to assess the stage of colorectal tumorigenesis at which chromosome 8p loss of heterozygosity (LOH) occurs, 56 sporadic adenomas were examined for LOH at four polymorphic loci which show frequent LOH in carcinomas. LOH was found in only 5 out of 51 (9.8%) informative adenomas, whereas studi...

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Autores principales: Cunningham, C., Dunlop, M. G., Bird, C. C., Wyllie, A. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033333/
https://www.ncbi.nlm.nih.gov/pubmed/8018534
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author Cunningham, C.
Dunlop, M. G.
Bird, C. C.
Wyllie, A. H.
author_facet Cunningham, C.
Dunlop, M. G.
Bird, C. C.
Wyllie, A. H.
author_sort Cunningham, C.
collection PubMed
description In order to assess the stage of colorectal tumorigenesis at which chromosome 8p loss of heterozygosity (LOH) occurs, 56 sporadic adenomas were examined for LOH at four polymorphic loci which show frequent LOH in carcinomas. LOH was found in only 5 out of 51 (9.8%) informative adenomas, whereas studies with the same markers in 85 informative carcinomas showed a LOH of 45%. The adenomas showing LOH were all in the 'high-risk' clinicopathological category, being 10 mm or more in diameter and showing tubulovillous architecture. It is concluded that the chromosome 8p locus is involved preferentially in the development of carcinomas rather than adenomas.
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spelling pubmed-20333332009-09-10 Deletion analysis of chromosome 8p in sporadic colorectal adenomas. Cunningham, C. Dunlop, M. G. Bird, C. C. Wyllie, A. H. Br J Cancer Research Article In order to assess the stage of colorectal tumorigenesis at which chromosome 8p loss of heterozygosity (LOH) occurs, 56 sporadic adenomas were examined for LOH at four polymorphic loci which show frequent LOH in carcinomas. LOH was found in only 5 out of 51 (9.8%) informative adenomas, whereas studies with the same markers in 85 informative carcinomas showed a LOH of 45%. The adenomas showing LOH were all in the 'high-risk' clinicopathological category, being 10 mm or more in diameter and showing tubulovillous architecture. It is concluded that the chromosome 8p locus is involved preferentially in the development of carcinomas rather than adenomas. Nature Publishing Group 1994-07 /pmc/articles/PMC2033333/ /pubmed/8018534 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Cunningham, C.
Dunlop, M. G.
Bird, C. C.
Wyllie, A. H.
Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
title Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
title_full Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
title_fullStr Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
title_full_unstemmed Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
title_short Deletion analysis of chromosome 8p in sporadic colorectal adenomas.
title_sort deletion analysis of chromosome 8p in sporadic colorectal adenomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033333/
https://www.ncbi.nlm.nih.gov/pubmed/8018534
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