Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy.

The viability of cells within the acidic microenvironment found in solid tumours is expected to depend on the regulation of intracellular pH (pHi). 5-(N,N-hexamethylene) amiloride (HMA) is a potent inhibitor of the Na+/H+ antiport, a major mechanism for the regulation of pHi. We have therefore studi...

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Detalles Bibliográficos
Autores principales: Luo, J., Tannock, I. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033413/
https://www.ncbi.nlm.nih.gov/pubmed/7917906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033413/
https://www.ncbi.nlm.nih.gov/pubmed/7917906

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