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Selective photodynamic inactivation of a multidrug transporter by a cationic photosensitising agent.

We have characterised sites of photodamage catalysed by the cationic photosensitiser tetrabromorhodamine 123, using P388 murine leukaemia cells and a subline (P388/ADR) which has a multidrug resistance phenotype and hyperexpresses mdr1 mRNA for P-glycoprotein. Fluorescence emission spectra were cons...

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Detalles Bibliográficos
Autores principales: Kessel, D., Woodburn, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033570/
https://www.ncbi.nlm.nih.gov/pubmed/7841045