Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients.

To test the role of serotonin in chemotherapy-induced nausea and emesis, ten cancer patients were pretreated with the serotonin synthesis inhibitor para-chlorophenylalanine (PCPA). PCPA (2 g 8 hourly for 2 or 3 days prior to cisplatin) reduced the spontaneous urinary excretion of 5-hydroxyindoleacet...

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Detalles Bibliográficos
Autores principales: Alfieri, A. B., Cubeddu, L. X.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033638/
https://www.ncbi.nlm.nih.gov/pubmed/7533519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033638/
https://www.ncbi.nlm.nih.gov/pubmed/7533519

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