Determinants of trimetrexate lethality in human colon cancer cells.

We examined the cytotoxicity and biochemical effects of the lipophilic antifol trimetrexate (TMQ) in two human colon carcinoma cell lines, SNU-C4 and NCI-H630, with different inherent sensitivity to TMQ. While a 24 h exposure to 0.1 microM TMQ inhibited cell growth by 50-60% in both cell lines, it d...

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Detalles Bibliográficos
Autores principales: Grem, J. L., Voeller, D. M., Geoffroy, F., Horak, E., Johnston, P. G., Allegra, C. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033700/
https://www.ncbi.nlm.nih.gov/pubmed/7981057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033700/
https://www.ncbi.nlm.nih.gov/pubmed/7981057

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