Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.

Previously we showed that tirapazamine (SR 4233, Win 59075) is cytotoxic towards hepatocytes under conditions of hypoxia but not in 10% or 95% oxygen and that bioreduction by DT-diaphorase or cytochrome P450 is not a major pathway. In the present study, we report that tirapazamine is highly cytotoxi...

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Detalles Bibliográficos
Autores principales: Khan, S., O'Brien, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033725/
https://www.ncbi.nlm.nih.gov/pubmed/7710944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033725/
https://www.ncbi.nlm.nih.gov/pubmed/7710944

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