Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase.

We report DNA interstrand cross-linking caused by the anti-tumour indoloquinone EO9 following reductive activation with purified rat liver DT-diaphorase or xanthine oxidase. Reduction was a necessary event for cross-linking to occur. DNA cross-link formation by EO9 following DT-diaphorase reduction...

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Detalles Bibliográficos
Autores principales: Maliepaard, M., Wolfs, A., Groot, S. E., de Mol, N. J., Janssen, L. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033736/
https://www.ncbi.nlm.nih.gov/pubmed/7536024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033736/
https://www.ncbi.nlm.nih.gov/pubmed/7536024

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