Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.

Resistance to anti-cancer drugs has proved to be a major barrier in the clinical management of neoplastic disease. We have investigated the mechanistic basis for resistance to folate-based thymidylate synthase (TS) inhibitors using two cell lines selected for resistance to ZD1694 (N-(5-[N-(3,4-dihyd...

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Detalles Bibliográficos
Autores principales: Freemantle, S. J., Jackman, A. L., Kelland, L. R., Calvert, A. H., Lunec, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033779/
https://www.ncbi.nlm.nih.gov/pubmed/7537519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033779/
https://www.ncbi.nlm.nih.gov/pubmed/7537519

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