Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.

A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient (SCID) mice. This antibody also reduced the mass of established tumours xenografted into S...

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Autores principales: Ohnishi, Y., Nakamura, H., Yoshimura, M., Tokuda, Y., Iwasawa, M., Ueyama, Y., Tamaoki, N., Shimamura, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033805/
https://www.ncbi.nlm.nih.gov/pubmed/7734322
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author Ohnishi, Y.
Nakamura, H.
Yoshimura, M.
Tokuda, Y.
Iwasawa, M.
Ueyama, Y.
Tamaoki, N.
Shimamura, K.
author_facet Ohnishi, Y.
Nakamura, H.
Yoshimura, M.
Tokuda, Y.
Iwasawa, M.
Ueyama, Y.
Tamaoki, N.
Shimamura, K.
author_sort Ohnishi, Y.
collection PubMed
description A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient (SCID) mice. This antibody also reduced the mass of established tumours xenografted into SCID mice, whereas gastric cancer not expressing c-ErbB-2 exhibited no regression in response to 4D5 treatment. In addition, administration of 4D5 prevented colonisation of cancer cells and prolonged the survival of host SCID mice inoculated i.v. with c-ErbB-2-overexpressing tumour cells. This is the first reported study to show that treatment with a single antibody specific to c-ErbB-2 prolongs the survival of host SCID mice bearing xenotransplanted tumours. IMAGES:
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spelling pubmed-20338052009-09-10 Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody. Ohnishi, Y. Nakamura, H. Yoshimura, M. Tokuda, Y. Iwasawa, M. Ueyama, Y. Tamaoki, N. Shimamura, K. Br J Cancer Research Article A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient (SCID) mice. This antibody also reduced the mass of established tumours xenografted into SCID mice, whereas gastric cancer not expressing c-ErbB-2 exhibited no regression in response to 4D5 treatment. In addition, administration of 4D5 prevented colonisation of cancer cells and prolonged the survival of host SCID mice inoculated i.v. with c-ErbB-2-overexpressing tumour cells. This is the first reported study to show that treatment with a single antibody specific to c-ErbB-2 prolongs the survival of host SCID mice bearing xenotransplanted tumours. IMAGES: Nature Publishing Group 1995-05 /pmc/articles/PMC2033805/ /pubmed/7734322 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ohnishi, Y.
Nakamura, H.
Yoshimura, M.
Tokuda, Y.
Iwasawa, M.
Ueyama, Y.
Tamaoki, N.
Shimamura, K.
Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
title Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
title_full Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
title_fullStr Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
title_full_unstemmed Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
title_short Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
title_sort prolonged survival of mice with human gastric cancer treated with an anti-c-erbb-2 monoclonal antibody.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033805/
https://www.ncbi.nlm.nih.gov/pubmed/7734322
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