Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalised increase in somatic mutation.

Hereditary non-polyposis colorectal cancer (HNPCC) has recently been linked to germline defects of DNA repair genes. Colorectal tumours in HNPCC frequently show DNA microsatellite instability, but it is not certain whether this mutator phenotype occurs throughout the morphologically normal colonic m...

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Detalles Bibliográficos
Autores principales: Williams, G. T., Geraghty, J. M., Campbell, F., Appleton, M. A., Williams, E. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033807/
https://www.ncbi.nlm.nih.gov/pubmed/7734304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033807/
https://www.ncbi.nlm.nih.gov/pubmed/7734304

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