Hyperthermia, thermotolerance and topoisomerase II inhibitors.

The cytoxicity of both intercalating (m-AMSA) and non-intercalating (VP16, VM26) topoisomerase II-targeting drugs is thought to occur via trapping DNA topoisomerase II on DNA in the form of cleavable complexes. First, analysis of cleavable complexes (detected as DNA double-strand breaks) by pulsed-f...

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Detalles Bibliográficos
Autor principal: Kampinga, H. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033976/
https://www.ncbi.nlm.nih.gov/pubmed/7640214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033976/
https://www.ncbi.nlm.nih.gov/pubmed/7640214

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