Characterisation of a human small-cell lung cancer cell line resistant to the DNA topoisomerase I-directed drug topotecan.

Camptothecins are DNA topoisomerase I-directed anti-tumour drugs with a novel mechanism of action. Topotecan (TPT), a hydrophilic derivative of camptothecin, is currently undergoing phase II clinical trials in small-cell lung cancer (SCLC). Human SCLC OC-NYH cells were made more than 6-fold resistan...

Descripción completa

Detalles Bibliográficos
Autores principales: Sorensen, M., Sehested, M., Jensen, P. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034011/
https://www.ncbi.nlm.nih.gov/pubmed/7640225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034011/
https://www.ncbi.nlm.nih.gov/pubmed/7640225

Ejemplares similares