Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity.

The present studies were initiated to quantitate the oxygen dependence of bioreductive metabolism-induced binding of EF5, a pentafluorinated derivative of the 2-nitroimidazole, etanidazole. Two different assays were compared: first, radioactive drug incorporation into cell lysates, which provides a...

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Detalles Bibliográficos
Autores principales: Koch, C. J., Evans, S. M., Lord, E. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034014/
https://www.ncbi.nlm.nih.gov/pubmed/7547233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034014/
https://www.ncbi.nlm.nih.gov/pubmed/7547233

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