DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid tumours and under hypoxic conditions. The levels of three reductive enzymes have been determined in t...

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Detalles Bibliográficos
Autores principales: Smitskamp-Wilms, E., Giaccone, G., Pinedo, H. M., van der Laan, B. F., Peters, G. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034035/
https://www.ncbi.nlm.nih.gov/pubmed/7547240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034035/
https://www.ncbi.nlm.nih.gov/pubmed/7547240

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