Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy.

A humanised IgG1/k version of A33 (hA33) has been constructed and expressed with yields up to 700 mg l-1 in mouse myeloma NS0 cells in suspension culture. The equilibrium dissociation constant of hA33 (KD = 1.3 nM) was shown to be equivalent to that of the murine antibody in a cell-binding assay. hA...

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Detalles Bibliográficos
Autores principales: King, D. J., Antoniw, P., Owens, R. J., Adair, J. R., Haines, A. M., Farnsworth, A. P., Finney, H., Lawson, A. D., Lyons, A., Baker, T. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034099/
https://www.ncbi.nlm.nih.gov/pubmed/8519646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034099/
https://www.ncbi.nlm.nih.gov/pubmed/8519646

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