Cargando…

Replication fork regression in vitro by the Werner syndrome protein (WRN): Holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity

The premature aging and cancer-prone disease Werner syndrome stems from loss of WRN protein function. WRN deficiency causes replication abnormalities, sensitivity to certain genotoxic agents, genomic instability and early replicative senescence in primary fibroblasts. As a RecQ helicase family membe...

Descripción completa

Detalles Bibliográficos
Autores principales: Machwe, Amrita, Xiao, Liren, Lloyd, Robert G., Bolt, Edward, Orren, David K.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034489/
https://www.ncbi.nlm.nih.gov/pubmed/17717003
http://dx.doi.org/10.1093/nar/gkm561