Evidence for Positive Selection in the C-terminal Domain of the Cholesterol Metabolism Gene PCSK9 Based on Phylogenetic Analysis in 14 Primate Species

BACKGROUND: Cholesterol homeostasis is maintained through finely tuned mechanisms regulating intestinal absorption, hepatic biosynthesis and secretion as well as plasma clearance. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted enzyme of the serine protease family that reduces ce...

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Detalles Bibliográficos
Autores principales: Ding, Keyue, McDonough, Samantha J., Kullo, Iftikhar J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034530/
https://www.ncbi.nlm.nih.gov/pubmed/17971861
http://dx.doi.org/10.1371/journal.pone.0001098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034530/
https://www.ncbi.nlm.nih.gov/pubmed/17971861
http://dx.doi.org/10.1371/journal.pone.0001098

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