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Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

BACKGROUND: The transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the γ-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer'...

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Detalles Bibliográficos
Autores principales: Madsen, Lone B, Thomsen, Bo, Larsen, Knud, Bendixen, Christian, Holm, Ida E, Fredholm, Merete, Jørgensen, Arne L, Nielsen, Anders L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034586/
https://www.ncbi.nlm.nih.gov/pubmed/17854491
http://dx.doi.org/10.1186/1471-2202-8-72