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Increase of calnexin gene dosage boosts the secretion of heterologous proteins by Hansenula polymorpha
The type I membrane protein calnexin is a conserved key component of the quality control mechanism in the endoplasmic reticulum. It functions as a molecular chaperone that monitors the folding state of nascent polypeptides entering the endoplasmic reticulum. Calnexin also behaves as a lectin, as its...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040192/ https://www.ncbi.nlm.nih.gov/pubmed/17617219 http://dx.doi.org/10.1111/j.1567-1364.2007.00271.x |