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Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity
Protein aggregation into amyloid fibrils and protofibrillar aggregates is associated with a number of the most common neurodegenerative diseases. We have established, using a computational approach, that knowledge of the primary sequences of proteins is sufficient to predict their in vitro aggregati...
Autores principales: | Luheshi, Leila M, Tartaglia, Gian Gaetano, Brorsson, Ann-Christin, Pawar, Amol P, Watson, Ian E, Chiti, Fabrizio, Vendruscolo, Michele, Lomas, David A, Dobson, Christopher M, Crowther, Damian C |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043051/ https://www.ncbi.nlm.nih.gov/pubmed/17973577 http://dx.doi.org/10.1371/journal.pbio.0050290 |
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