Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence

The adaptive immune response requires waves of T-cell clonal expansion on contact with altered self and contraction after elimination of antigen. In the case of persisting antigen, as occurs for example in cytomegalovirus or Epstein–Barr virus infection, this critical process can become dysregulated...

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Detalles Bibliográficos
Autores principales: Mazzatti, Dawn J, White, Andrew, Forsey, Rosalyn J, Powell, Jonathan R, Pawelec, Graham
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2007
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049045/
https://www.ncbi.nlm.nih.gov/pubmed/17286612
http://dx.doi.org/10.1111/j.1474-9726.2007.00269.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049045/
https://www.ncbi.nlm.nih.gov/pubmed/17286612
http://dx.doi.org/10.1111/j.1474-9726.2007.00269.x

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