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New antimetabolites in cancer chemotherapy and their clinical impact.
It is almost 50 years since antimetabolites were first found to have clinical antitumour activity, with Farber's discovery that aminopterin could cause remission in acute leukaemia. In the following 10 years, methotrexate, 6-mercaptopurine and 5-fluorouracil (5-FU) found their way into clinical...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group|1
1998
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062805/ https://www.ncbi.nlm.nih.gov/pubmed/9717984 |