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Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group|1
1998
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063101/ https://www.ncbi.nlm.nih.gov/pubmed/9716031 |