Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.

The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in...

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Autores principales: Armstrong, J. F., Hooper, M. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063101/
https://www.ncbi.nlm.nih.gov/pubmed/9716031
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author Armstrong, J. F.
Hooper, M. L.
author_facet Armstrong, J. F.
Hooper, M. L.
author_sort Armstrong, J. F.
collection PubMed
description The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.
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spelling pubmed-20631012009-09-10 Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice. Armstrong, J. F. Hooper, M. L. Br J Cancer Research Article The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice. Nature Publishing Group|1 1998-08 /pmc/articles/PMC2063101/ /pubmed/9716031 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Armstrong, J. F.
Hooper, M. L.
Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
title Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
title_full Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
title_fullStr Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
title_full_unstemmed Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
title_short Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.
title_sort inbreeding abolishes the effect of parental origin of a mutant rb-1 allele on pituitary tumorigenesis in mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063101/
https://www.ncbi.nlm.nih.gov/pubmed/9716031
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