The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was c...

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Detalles Bibliográficos
Autores principales: Houba, P. H., Boven, E., Erkelens, C. A., Leenders, R. G., Scheeren, J. W., Pinedo, H. M., Haisma, H. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063245/
https://www.ncbi.nlm.nih.gov/pubmed/9862570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063245/
https://www.ncbi.nlm.nih.gov/pubmed/9862570

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